Microphthalmia-associated transcription factor interacts with LEF-1, a mediator of Wnt signaling
نویسندگان
چکیده
منابع مشابه
A novel role for Lef-1, a central transcription mediator of Wnt signaling, in leukemogenesis
Canonical Wnt signaling is critically involved in normal hematopoietic development and the self-renewal process of hematopoietic stem cells (HSCs). Deregulation of this pathway has been linked to a large variety of cancers, including different subtypes of leukemia. Lef-1 is a major transcription factor of this pathway and plays a pivotal role in lymphoid differentiation as well as in granulopoi...
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Members of the Wnt family of secreted molecules have been established as key factors in determining cell fate and morphogenic signaling. It has long been recognized that Wnt induces morphogenic signaling through the Tcf/LEF-1 cascade by regulating free intracellular levels of -catenin, a co-factor for Tcf/LEF-1 transcription factors. In the present study, we have demonstrated that Wnt-3A can al...
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Wnt signaling functions repeatedly during embryonic development to induce different but specific responses. What molecular mechanisms ensure that Wnt signaling triggers the correct tissue-specific response in different tissues? Early Xenopus development is an ideal model for addressing this fundamental question, since there is a dramatic change in the response to Wnt signaling at the onset of z...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 2002
ISSN: 1460-2075
DOI: 10.1093/emboj/21.11.2703